Prognostic of significance of cardio-ankle vascular index in new diagnosed idiopathic pulmonary hypertension
In previous studies, the cardio-ankle vascular index (CAVI) was increased significantly in idiopathic pulmonary arterial hypertension (IPAH) patients compared with the healthy group and did not differ much from that in systemic hypertensives. In this study, the...
Increased bone morphogenetic protein 10 activity is associated with increased right atrial wall stress and disease severity in precapillary pulmonary hypertension
Background: Pulmonary hypertension (PH) is characterized by increased right atrial (RA) stretch and pressure. The major genetic predisposing risk factor for PH involves mutations in bone morphogenetic protein (BMP) receptor 2 (BMPR2), for which BMP9 and BMP10 are...
Oxygenated hemoglobin as prognostic marker among patients with systemic sclerosis screened for pulmonary hypertension
Background: Oxygenated hemoglobin (OxyHem) in arterial blood may reflect disease severity in patients with systemic sclerosis (SSc), particularly among those with pulmonary manifestations, such as pulmonary hypertension (PH). Objectives: Hence, the aim of this study...
Increase in progenitor endothelial cells associated to right heart failure in pediatric patients with secondary pulmonary arterial hypertension
Background: Pulmonary arterial hypertension (PAH) is a serious condition that causes right heart failure. A persistent inflammatory process is present in the vascular endothelial tissue, which releases circulating CD34+,133+ endothelial progenitor cells (EPCs),...
Analysis of risk assessment tools in the REPLACE study
Purpose: The REPLACE study showed that PAH patients treated with phosphodiesterase-5 inhibitors (PDE5i) still at intermediate risk could achieve clinical improvement when switched to riociguat. Significant improvements in risk status with riociguat versus PDE5i were...
Effect of digoxin use on mortality in pulmonary arterial hypertension: A single center experience
Background: Digoxin increases cardiac output modestly in acute settings in patients with pulmonary arterial hypertension (PAH) and right ventricular failure; however, very little is known about the effects of chronic digoxin therapy in PAH. Methods: We studied 251...
Clinical characteristics, management and survival of patients with idiopathic pulmonary arterial hypertension with cardiovascular comorbidities: Data from the Hellenic Pulmonary Hypertension Registry (HOPE)
Background: Although younger female patients were diagnosed with idiopathic pulmonary arterial hypertension (IPAH) in 1980s, it is now frequently encountered in elderly patients with cardiovascular comorbidities (CVCs) associated with increased risk for left heart...
Association of right ventricular diastolic stiffness and CMR variables with mortality in patients with pulmonary hypertension.
Right ventricular (RV) failure is the major cause of mortality in pulmonary hypertension (PH). Diastolic stiffness is significantly associated with outcomes in patients with PH. Cardiac magnetic resonance (CMR) imaging provides an opportunity to image the right...
