Acute hemodynamic improvement in chronic pulmonary arterial hypertension on dual therapy following RT234 inhalation

Acute hemodynamic improvement in chronic pulmonary arterial hypertension on dual therapy following RT234 inhalation

RT234 is an inhaled formulation of the phosphodiesterase type-5 inhibitor (PDE5i) vardenafil, in development for episodic symptoms of pulmonary arterial hypertension (PAH). This phase 2a escalating-dose trial evaluated acute changes in pulmonary vascular resistance...
Inhaled iloprost improves right ventricular load-independent contractility in pulmonary hypertension

Inhaled iloprost improves right ventricular load-independent contractility in pulmonary hypertension

Background: The adaptation of the right ventricular contractility to its afterload (RV–PA coupling), best measured by the ratio of end-systolic elastance (Ees) and arterial elastance (Ea), is a key determinant for prognosis and symptomatology in pulmonary hypertension...
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